[4], Imipenem/cilastatin is used for lower respiratory tract infections, urinary tract infections, intra-abdominal infections, gynecologic infections, bacterial sepsis, bone and joint infections, skin and skin structure infections, endocarditis and polymicrobic infections. Powder for solution for infusion 1 × 20ml Vial per pack. 750mg imipenem and 750mg cilastatin power mixture for intramuscular injection. It is given by injection into a vein or muscle. Dosage. View all Brand Names Innovator's Monograph Indications The activity of Cilastatin & Imipenem against an unusually broad spectrum of pathogens makes it particularly useful in the treatment of polymicrobic mixed aerobic/anaerobic infections as well as initial therapy prior to … [1], Common side effects include nausea, diarrhea, and pain at the site of injection. Last updated on Oct 16, 2020. Bacteremia. H2O that is derived from a bacterium (Streptomyces cattleya) and is effective against gram-negative and gram-positive bacteria. What is imipenem and cilastatin (Primaxin IM, Primaxin IV, Primaxin IV ADD-Vantage)? Imipenem (N-formimidoylthienamycin monohydrate) is a crystalline derivative of thienamycin, which is produced by Streptomyces cattleya. As a result, the antibiotic stays in the body and can work for longer. Imipenem inhibits bacterial cell-wall synthesis by binding to penicillin-binding proteins; cilastatin prevents renal metabolism of imipenem. Bone infection. Imipenem-Cilastatin Suspension For Reconstitution. Imipenem and other carbapenems have not been linked to cases of acute liver failure. Primaxin IM lacks the sodium bicarbonate buffer. - 500 INJECTION. … The .gov means it’s official. Imipenem+Cilastatin+500500 Mg 1 Unit Parenteral Use. USES: This medication is used to treat a wide variety of bacterial infections.This medication is known as a carbapenem-type antibiotic. It works by killing bacteria. Imipenem is in a class of medications called carbapenem antibiotics. Imipenem (trade name Primaxin among others) is an intravenous β-lactam antibiotic discovered by Merck scientists Burton Christensen, William Leanza, and Kenneth Wildonger in the mid-1970s. [1] Cilastatin blocks the activity of dehydropeptidase I which prevents the breakdown of imipenem. Search results for imipenem at Sigma-Aldrich. 1 Articles and resources. Identification of the Substance/Mixture and of the Company/Undertaking Product Name: Imipenem (hydrate) Company Name: Cayman Chemical Company 1180 E. Ellsworth Rd. The brand name for imipenem and cilastatin is Primaxin. [2] Imipenem is in the carbapenem family of medications and works by interfering with the bacteria's cell wall. A recently published phase III study, The RESTORE IMI-1 demonstrated safety and tolerability in patients infected with carbapenem non-susceptible bacterial pathogens [ 3 ]. 1907/2006 as amended by (EC) No. Imipenem-Cilastatin SODIUM Vial Side Effects by Likelihood and Severity COMMON side effects. [9] The brand name of the imipenem-cilastatin combination is Primaxin, and the prescribed dose of Primaxin is understood to refer to the amount of the imipenem component being administered. [6] Primaxin is cleared from the body by the kidneys, so it is important to tell one's doctor about any other drugs being taken that are also cleared through the kidneys (such as other antibiotics), especially for older patients, as kidney function declines with age. Drug Name : Imipenem and Cilastatin Imipenem and Cilastatin (Primaxin) generic is a … In large clinical trials, imipenem was associated with transient and asymptomatic elevations in serum aminotransferase levels in about 6% of patients given the drug for five to 14 days. [5][6], It is a broad-spectrum beta-lactam containing equal quantities of imipenem and cilastatin. In 2019, it was approved for use in the United States for the treatment of complicated urinary tract and complicated intra-abdominal infections. More serious hepatic injury from imipenem/cilastatin is rare, but jaundice and liver test abnormalities have been reported in 0.1% of patients in prospective trials of the agent. It has activity against many aerobic and anaerobic Gram-positive and Gram-negative organisms, including Staphylococcus aureus, Streptococcus pyogenes, S. agalactiae, S. viridans- group streptococci, Enterococcus faecalis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Bacteroides fragilis and Peptostreptococcus species. Generic Name: Imipenem and Cilastatin (i mi PEN em & sye la STAT in) Brand Name: Primaxin I.V. cilastatin/imipenem systemic. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Search results for Imipenem at Sigma-Aldrich. [3] It is on the World Health Organization's List of Essential Medicines. Bronchitis. Its chemical name is [5 R - [5α, 6α (R *)]]-6- (1-hydroxyethyl) -3- [ [2- [ (iminomethyl) amino] ethyl]thio]-7-oxo-1-azabicyclo [3.2.0] hept … The company that markets these medicines is Merck, Sharp & Dohme. Buy Imipenem Online. Imipenem (hydrate) SAFETY DATA SHEET Supersedes Revision: 10/28/2014 according to Regulation (EC) No. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. * Tienam I.V. Cilastatin is in a class of medications called dehydropeptidase inhibitors. Compare Products: Select up to 4 products. * Each vial contains: Imipenem monohydrate equivalent to 500 mg imipenem anhydrous, and Cilastatin sodium equivalent to 500 mg Cilastatin acid, with 21 mg Sodium Bicarbonate. [5][6], Patients who are allergic to penicillin, cephalosporins, and related drugs may react to imipenem. Intravenous: 250mg imipenem, 250mg cilastatin, and 10mg sodium bicarbonate power mixture for intravenous injection. This antibiotic is used to treat serious infections that are mild to moderate in severity, such as lower respiratory infection, heart valve infection, infection caused by a burst appendix, and some abscesses. Little information is available on possible cross-sensitivity to liver injury among the different betalactam antibiotics, but patients with clinically apparent liver injury due to imipenem should probably avoid the other carbapenems. [1] Other side effects may include Clostridium difficile diarrhea and allergic reactions including anaphylaxis. Imipenem is metabolized in the kidney by dehydropeptidase 1; activity is blocked by cilastatin. Important: The information below refers to products available in the United States that contain imipenem. Continue Learning about Antibiotic 6 Ailments That Call for an Antibiotic Application Number. *Please select more than one item to compare OTHER NAME(S): Imipenem-Cilastatin Suspension For Reconstitution Imipenem/cilastatin was approved for use in the United States in 1985. Find imipenem at best price offered by imipenem manufacturers, imipenem suppliers, dealers, traders and exporters. COMMON BRAND(S): Primaxin. Imipenem and cilastatin is a combination medicine used to treat severe infections of the heart, lungs, bladder, kidneys, skin, blood, bones, joints, stomach, or female reproductive organs. Wall integrity and synthesis contain imipenem has been within one to three weeks and., Intramuscular Route ) Description and brand Names - Mayo Clinic Mg 1 Parenteral! Moq & product details min ; prolonged with renal impairment for trustworthy health information -, the. Aspiration pneumonia 3 ] it is given by injection into a vein or muscle range imipenem! 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